Acetyl Tetrapeptide-3
Acetyl Tetrapeptide-3
Overview
Acetyl Tetrapeptide-3 is a synthetic biomimetic tetrapeptide that stimulates extracellular matrix proteins in the scalp and promotes hair follicle anchoring and growth. It is primarily used as a cosmetic ingredient in anti-hair loss formulations and has shown clinical efficacy in reducing hair loss and improving hair density in controlled studies. Unlike hormonal approaches to hair loss Acetyl Tetrapeptide-3 works by strengthening the structural support of the hair follicle in the scalp making it particularly useful for diffuse thinning and age-related hair loss where follicle miniaturization is the primary mechanism.
Mechanism of Action
Acetyl Tetrapeptide-3 mimics the signal peptides involved in extracellular matrix remodeling around hair follicles. It stimulates the synthesis of laminin-5 and collagen IV in the dermal papilla and basement membrane — structural proteins that anchor hair follicles in the scalp and maintain their integrity. By reinforcing the follicle anchoring structure Acetyl Tetrapeptide-3 reduces hair shedding and extends the anagen growth phase. It also activates stem cell niches in the hair follicle bulge region promoting the differentiation of progenitor cells into new hair matrix cells. Clinical studies have demonstrated significant reductions in hair loss measured by phototrichogram and improvements in hair density and thickness comparable to minoxidil-containing formulations when used at effective concentrations.
Where does Acetyl Tetrapeptide-3 sit?
See how this peptide compares across all 85 peptides in our database.
Dosage Information
Typical Dose
500 ppm (0.05%) in topical formulation
Frequency
Twice daily application to affected areas
Administration
Topical serum or lotion
Notes
Most clinical evidence uses concentrations of 500-3000 ppm. Often combined with other hair peptides like biotinoyl tripeptide-1 for synergistic effects. Results typically visible after 3-4 months of consistent use.
Compound Data
Molecular Formula
C22H39N9O5
Molecular Weight
509.60 g/mol
IUPAC Name
(2S)-2-[[(2S)-2-[[2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanamide
PubChem CID
11752568Potential Side Effects
Community Experiences
No experiences shared yet. Be the first!
Quick Facts
- Administration
- Topical serum or lotion
- Typical Dose
- 500 ppm (0.05%) in topical formulation
- Frequency
- Twice daily application to affected areas
- References
- 0 curated + 1 from PubMed
- Evidence Score
- 12.3 / 100