Skin HealthPreclinical

AHK-Cu

Ala-His-Lys Copper Complex

AI explanation

AHK-Cu: A Hair Growth Peptide

AHK-Cu is a small protein fragment — just three amino acids linked to copper — that your body naturally produces in hair follicles. People use it because it specifically targets hair loss by waking up dormant hair follicles and pushing them back into their growth phase. Think of your hair follicles like they're in a sleep cycle; this peptide is essentially a targeted alarm clock.

Here's how it actually works: Your hair follicles contain stem cells in a region called the bulge, kind of like a backup factory for hair production. When AHK-Cu shows up, it tells these stem cells to wake up and start multiplying. The copper in the complex acts like a key, unlocking specific cellular processes. Once activated, these stem cells transform into the specialized cells that actually build your hair shaft.

But the peptide doesn't stop there. It also tells your follicles to improve their blood supply by triggering growth factors like VEGF — essentially upgrading the nutrient delivery system to your hair roots. It simultaneously cranks up other growth signals (KGF and HGF) that specifically control whether your hair follicles are in rest mode or active growth mode. So it's working on multiple levels at once: activating dormant cells, improving blood flow, and signaling the follicle to enter its growth phase rather than staying dormant.

Dosage Information

Typical Dose

0.1-0.5% concentration in topical formulation

Frequency

Once or twice daily application to scalp

Evening

Administration

Topical serum or solution

Half-Life

~2 hours

estimated

Notes

Often combined with GHK-Cu for complementary mechanisms. Leave-on serums provide better contact time than shampoos. Results typically visible after 3-4 months consistent use.

Why this matters

Topical copper peptide; local tissue retention matters more than plasma half-life.

Protocol cycle

continuous· Once or twice daily topical application, results in 3-4 months

Where does AHK-Cu sit?

See how this peptide compares across all 150 peptides in our database.

Evidence Score

0.17

Clinical trials
0.0035%
Literature
0.1230%
Community
0.0020%
Completeness
0.8815%

Compound Data

AHK-Cu structure

Molecular Formula

C15H24ClCuN6O4-

Molecular Weight

451.39 g/mol

IUPAC Name

copper;(2S)-6-amino-2-[[(2S)-2-[(2S)-2-azanidylpropanoyl]azanidyl-3-(1H-imidazol-4-yl)propanoyl]amino]hexanoate;hydrochloride

PubChem CID

168431292

Potential Side Effects

Very well tolerated topicallyScalp irritation in sensitive individuals (rare)No known systemic effects at topical doses
Pep Talk

AHK-Cu discussions

Quick Facts

Administration
Topical serum or solution
Typical Dose
0.1-0.5% concentration in topical formulation
Frequency
Once or twice daily application to scalp
References
0 curated + 6 from PubMed
Evidence Score
0.2 / 100

Frequently Asked Questions about AHK-Cu

What is AHK-Cu?

AHK-Cu (Alanine-Histidine-Lysine copper complex) is a copper-binding tripeptide that functions as a hair follicle stimulator and anagen phase promoter. It was identified as a naturally occurring peptide in human hair follicles and has demonstrated potent hair growth stimulating activity in vitro and in preliminary clinical studies. AHK-Cu activates hair follicle stem cells and promotes the transition from telogen (resting) to anagen (growth) phase making it one of the most targeted hair regrowth peptides available. It is increasingly included in advanced hair loss formulations alongside GHK-Cu.

How does AHK-Cu work?

AHK-Cu acts through copper-dependent mechanisms in hair follicle stem cell niches. The copper complex activates stem cell proliferation in the hair follicle bulge region and promotes the differentiation of these stem cells into hair matrix cells that form the hair shaft. AHK-Cu stimulates the expression of vascular endothelial growth factor (VEGF) in the dermal papilla improving follicular blood supply and nutrient delivery. It also upregulates keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF) — key growth factors for hair follicle cycling. Unlike GHK-Cu which has broader tissue remodeling effects AHK-Cu appears to have more specific activity on hair follicle biology making it potentially more targeted for hair loss applications.

What is the recommended dosage for AHK-Cu?

The typical dose is 0.1-0.5% concentration in topical formulation. Once or twice daily application to scalp. Administration: Topical serum or solution. Often combined with GHK-Cu for complementary mechanisms. Leave-on serums provide better contact time than shampoos. Results typically visible after 3-4 months consistent use.

What are the side effects of AHK-Cu?

Very well tolerated topically. Scalp irritation in sensitive individuals (rare). No known systemic effects at topical doses

What is the AHK-Cu cycle protocol?

AHK-Cu is typically cycled continuous. Once or twice daily topical application, results in 3-4 months

Questions reflect common community inquiries. This is not medical advice.