Angiotensin 1-7: A Protective Balance in Your Body
Angiotensin 1-7 is a small protein fragment that acts like your body's natural brake pedal on inflammation and blood vessel tightness. People study it because it appears to protect your heart, kidneys, and metabolic health—essentially doing the opposite of what another similar molecule called angiotensin II does, which tightens vessels and promotes inflammation.
Here's how it works: Think of your body as having two competing systems in charge of blood pressure and inflammation. Angiotensin II is the "go" signal—it makes blood vessels constrict and triggers inflammation. Angiotensin 1-7 is the "ease off" signal. Your body produces angiotensin 1-7 using an enzyme called ACE2, which acts like a converter transforming one molecule into another. Once created, angiotensin 1-7 docks onto special receivers in your cells called Mas receptors, which then release a relaxing chemical called nitric oxide. This widening of blood vessels, reduction in inflammation, and better insulin sensitivity all flow from that single activation. Your kidneys and heart seem especially responsive to this protection. The balance between these two competing systems largely determines your cardiovascular health—so maintaining enough angiotensin 1-7 is increasingly seen as important for preventing heart disease and metabolic problems.
Dosage Information
Typical Dose
Research compound — no established human therapeutic dosing
Frequency
N/A for therapeutic use
Administration
Intravenous or subcutaneous in research
Half-Life
~10 seconds
Notes
Several formulations are in clinical trials including inhaled versions for COVID-19 complications. Not currently available as a commercial therapeutic outside of trials.
Why this matters
Extremely rapid degradation; research use only with specialized formulations.
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Where does Angiotensin 1-7 sit?
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Evidence Score
0.67
Compound Data
Molecular Formula
C41H62N12O11
Molecular Weight
899.00 g/mol
IUPAC Name
(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid
PubChem CID
123805Potential Side Effects
Angiotensin 1-7 discussions
Quick Facts
- Administration
- Intravenous or subcutaneous in research
- Typical Dose
- Research compound — no established human therapeutic dosing
- Frequency
- N/A for therapeutic use
- References
- 0 curated + 49 from PubMed
- Clinical Trials
- 50 registered
- Evidence Score
- 0.7 / 100
Frequently Asked Questions about Angiotensin 1-7
What is Angiotensin 1-7?
Angiotensin 1-7 is a seven-amino-acid peptide component of the renin-angiotensin system (RAS) that acts as a counter-regulatory axis to the classical angiotensin II pathway. While angiotensin II promotes vasoconstriction inflammation and fibrosis angiotensin 1-7 has opposing vasodilatory anti-inflammatory and anti-fibrotic effects. It has been studied extensively for cardiovascular protection kidney disease COVID-19 complications and metabolic syndrome. Interest in angiotensin 1-7 increased dramatically during the COVID-19 pandemic when ACE2 — the enzyme that produces angiotensin 1-7 — was identified as the SARS-CoV-2 receptor.
How does Angiotensin 1-7 work?
Angiotensin 1-7 is produced from angiotensin II by ACE2 (angiotensin-converting enzyme 2) and acts through the Mas receptor — a G-protein-coupled receptor that mediates its protective cardiovascular and anti-inflammatory effects. Mas receptor activation opposes angiotensin II signaling by promoting nitric oxide release causing vasodilation reducing oxidative stress and inhibiting NF-κB-mediated inflammation. In the kidney angiotensin 1-7 reduces fibrosis and protects against hypertensive nephropathy. In the heart it improves cardiac function after injury and reduces pathological remodeling. In metabolic disease it improves insulin sensitivity and reduces adipose inflammation. The ACE/ACE2 balance — producing angiotensin II vs angiotensin 1-7 respectively — is a major determinant of cardiovascular risk and has become a key target in hypertension and cardiometabolic therapeutics.
What is the recommended dosage for Angiotensin 1-7?
The typical dose is Research compound — no established human therapeutic dosing. N/A for therapeutic use. Administration: Intravenous or subcutaneous in research. Several formulations are in clinical trials including inhaled versions for COVID-19 complications. Not currently available as a commercial therapeutic outside of trials.
What are the side effects of Angiotensin 1-7?
Research compound — limited safety data outside clinical trials. Hypotension with vasodilatory effects (dose-dependent). Generally well tolerated in completed trials
Questions reflect common community inquiries. This is not medical advice.