Biotinoyl Tripeptide-1
Biotinoyl-GHK (Biotin-Gly-His-Lys)
Overview
Biotinoyl Tripeptide-1 is a synthetic peptide combining biotin (vitamin B7) with the GHK tripeptide sequence creating a compound that combines biotin's role in keratin production with GHK's proven tissue repair and growth stimulation properties. It is widely used in cosmetic hair care formulations and has demonstrated efficacy in clinical studies for reducing hair loss strengthening hair fibers and improving scalp health. The biotin component supports keratin biosynthesis while the GHK sequence activates follicular stem cells and promotes scalp tissue repair.
Mechanism of Action
Biotinoyl Tripeptide-1 works through dual mechanisms. The biotin component serves as an essential cofactor for carboxylase enzymes involved in fatty acid synthesis and amino acid metabolism — processes critical for keratin production in hair matrix cells. Biotin deficiency is a well-established cause of hair loss and the biotin in this peptide directly supports the keratin production machinery in hair follicles. The GHK sequence (glycyl-histidyl-lysine) activates copper-dependent enzymes in the scalp promotes collagen and glycosaminoglycan synthesis in the dermal papilla and stimulates follicular stem cell activity. The conjugation of biotin to GHK improves the peptide's penetration into the follicular unit and localizes biotin delivery specifically to the site of keratin production rather than providing systemic biotin supplementation.
Where does Biotinoyl Tripeptide-1 sit?
See how this peptide compares across all 85 peptides in our database.
Dosage Information
Typical Dose
0.1-0.5% concentration in topical formulation
Frequency
Once or twice daily application
Administration
Topical serum or shampoo
Notes
Frequently paired with Acetyl Tetrapeptide-3 and other hair peptides. Used in both leave-on and rinse-off formulations though leave-on provides superior contact time.
Compound Data
Molecular Formula
C24H38N8O6S
Molecular Weight
566.70 g/mol
IUPAC Name
(2S)-2-[[(2S)-2-[[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoic acid
PubChem CID
11534242Potential Side Effects
Community Experiences
No experiences shared yet. Be the first!
Quick Facts
- Administration
- Topical serum or shampoo
- Typical Dose
- 0.1-0.5% concentration in topical formulation
- Frequency
- Once or twice daily application
- References
- 0 curated + 46 from PubMed
- Evidence Score
- 46.1 / 100