BMP-7 Peptide
BMP-7 is a growth factor that your body naturally produces, but in small amounts. Doctors use it as a treatment to help your bones and cartilage heal and rebuild themselves. It's already FDA-approved for spine fusion and broken bones, and researchers are finding it works really well for joint damage from osteoarthritis—that wear-and-tear arthritis that affects millions of people.
What makes BMP-7 special is that it's one of the few growth factors that rebuilds both bone *and* cartilage at the same time, which is why it's so promising for damaged joints.
Here's how it actually works in your body: When you apply BMP-7, it acts like a messenger that locks onto specific receptors on your bone and cartilage cells—think of it like a key fitting into a lock. Once it connects, it triggers a chain reaction inside those cells that tells them to start producing the tough, flexible materials that make up healthy cartilage, like collagen and other structural proteins. At the same time, it pumps the brakes on the enzymes that break down cartilage, which is what happens during arthritis. It even counteracts inflammatory signals that normally accelerate joint damage. Essentially, BMP-7 shifts your joint environment from a destructive state toward one that rebuilds and repairs itself.
Dosage Information
Typical Dose
3.5 mg per implant site (FDA-approved spinal use)
Frequency
Single application during surgical procedure
Administration
Surgical implantation in collagen carrier (approved use); intra-articular injection (research)
Half-Life
~30 minutes
estimatedNotes
FDA-approved as Osigraft/OP-1 for specific orthopedic indications. Research into intra-articular injection for OA is ongoing. Peptide mimetics are in preclinical development.
Why this matters
Bone morphogenetic protein; short systemic half-life with local bone effects.
Protocol cycle
Dose Calculator
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Concentration: 2,500 mcg/mL
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Evidence Score
0.63
Potential Side Effects
BMP-7 Peptide discussions
Quick Facts
- Administration
- Surgical implantation in collagen carrier (approved use); intra-articular injection (research)
- Typical Dose
- 3.5 mg per implant site (FDA-approved spinal use)
- Frequency
- Single application during surgical procedure
- References
- 0 curated + 50 from PubMed
- Clinical Trials
- 23 registered
- Evidence Score
- 0.6 / 100
Frequently Asked Questions about BMP-7 Peptide
What is BMP-7 Peptide?
BMP-7 (Bone Morphogenetic Protein 7 also known as Osteogenic Protein-1 or OP-1) is an FDA-approved growth factor for spinal fusion and long bone fractures with additional research evidence for cartilage regeneration in osteoarthritis. Unlike most other BMPs BMP-7 has potent chondrocyte-anabolic effects stimulating cartilage matrix synthesis in addition to its bone-forming properties. It is one of the most advanced growth factors for combined bone and cartilage regeneration and peptide mimetics of BMP-7 are in development to provide the regenerative activity without the challenges of producing full-length recombinant protein.
How does BMP-7 Peptide work?
BMP-7 signals through BMP receptor complexes (BMPR1 and BMPR2) activating SMAD1/5/8 transcription factors that regulate genes involved in chondrocyte and osteoblast differentiation and matrix production. In chondrocytes BMP-7 stimulates synthesis of type II collagen aggrecan and other cartilage matrix components while inhibiting catabolic enzymes including metalloproteinases and aggrecanases. BMP-7 also counteracts the catabolic effects of IL-1β and TNF-α providing a pro-anabolic signal in the inflammatory joint environment. Its chondrogenic potency — stimulating cartilage matrix synthesis in adult chondrocytes — has been confirmed in multiple in vitro systems and animal OA models. Peptide mimetics of the BMP-7 knuckle epitope that mediates receptor binding are in research development as more stable and producible alternatives to the full protein.
What is the recommended dosage for BMP-7 Peptide?
The typical dose is 3.5 mg per implant site (FDA-approved spinal use). Single application during surgical procedure. Administration: Surgical implantation in collagen carrier (approved use); intra-articular injection (research). FDA-approved as Osigraft/OP-1 for specific orthopedic indications. Research into intra-articular injection for OA is ongoing. Peptide mimetics are in preclinical development.
What are the side effects of BMP-7 Peptide?
Heterotopic ossification — bone formation outside intended site (uncommon). Antibody formation (uncommon with repeat use). Inflammatory reaction at implant site (uncommon). Oncogenic concern with high doses (theoretical — BMPs are growth factors)
What is the BMP-7 Peptide cycle protocol?
BMP-7 Peptide is typically cycled single application. One-time surgical implantation; no cycling protocol
Questions reflect common community inquiries. This is not medical advice.