CJC-1295 No DAC Explained
CJC-1295 No DAC is a synthetic peptide that tells your pituitary gland to produce more growth hormone. People use it because growth hormone naturally declines with age, and this peptide essentially reminds your body to make more of it—similar to how your body did when you were younger.
Here's how it actually works: Your pituitary gland is like a hormone factory, and growth hormone is one of its key products. Normally, a natural signal called GHRH arrives and says "time to release growth hormone." CJC-1295 No DAC mimics that signal perfectly. It's a slight tweak on the natural messenger—just stable enough to stick around for 30 to 60 minutes instead of the original 2 minutes—but not so stable that it floods your system constantly.
The "No DAC" part matters because without it, the peptide creates pulses rather than a constant drip. Your body naturally releases growth hormone in waves, and this version respects that rhythm, which feels more natural to your system.
When combined with other peptides like GHRP-2, they work as a team: one increases how much hormone gets released per pulse, the other increases how often those pulses happen. Together, they produce significantly more growth hormone than either could alone.
Dosage Information
Typical Dose
100 mcg per dose
Frequency
2-3 times daily, typically combined with a GHRP
Administration
Subcutaneous injection
Half-Life
25–30 minutes
Notes
Almost always stacked with a GHRP (Ipamorelin, GHRP-2, or GHRP-6) for synergistic GH release. Administer on empty stomach and avoid eating for 30-40 minutes post-injection to maximize GH pulse.
Why this matters
Very short half-life without DAC; typically dosed before bed or pre-workout for a GH pulse.
Protocol cycle
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Where does CJC-1295 No DAC sit?
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Evidence Score
0.58
Potential Side Effects
CJC-1295 No DAC discussions
Quick Facts
- Administration
- Subcutaneous injection
- Typical Dose
- 100 mcg per dose
- Frequency
- 2-3 times daily, typically combined with a GHRP
- References
- 0 curated + 14 from PubMed
- Clinical Trials
- 13 registered
- Evidence Score
- 0.6 / 100
Frequently Asked Questions about CJC-1295 No DAC
What is CJC-1295 No DAC?
CJC-1295 No DAC (also called Modified GRF 1-29 or Mod GRF 1-29) is a modified version of the first 29 amino acids of GHRH without the Drug Affinity Complex (DAC) used in standard CJC-1295. Without DAC the peptide has a shorter half-life of 30-60 minutes compared to CJC-1295 DAC's week-long duration. This shorter half-life is often considered advantageous as it produces a more physiological pulsatile GH release pattern rather than the continuous elevation from CJC-1295 with DAC. It is one of the most widely used GHRH analogs in combination with GHRP peptides.
How does CJC-1295 No DAC work?
Mod GRF 1-29 binds to GHRH receptors on pituitary somatotrophs stimulating GH synthesis and pulsatile release through the same mechanism as endogenous GHRH. The four amino acid substitutions from native GHRH 1-29 improve stability against enzymatic degradation extending the half-life from the 2 minutes of native GHRH to 30-60 minutes without altering receptor binding affinity. When combined with a GHRP peptide (such as Ipamorelin or GHRP-2) the two compounds work synergistically — GHRH analogs increase the amount of GH released per pulse while GHRPs increase the frequency and amplitude of pulses producing GH release significantly greater than either compound alone.
What is the recommended dosage for CJC-1295 No DAC?
The typical dose is 100 mcg per dose. 2-3 times daily, typically combined with a GHRP. Administration: Subcutaneous injection. Almost always stacked with a GHRP (Ipamorelin, GHRP-2, or GHRP-6) for synergistic GH release. Administer on empty stomach and avoid eating for 30-40 minutes post-injection to maximize GH pulse.
What are the side effects of CJC-1295 No DAC?
Water retention (uncommon). Tingling or numbness in extremities (uncommon). Fatigue (uncommon). Injection site irritation (uncommon)
What is the CJC-1295 No DAC cycle protocol?
CJC-1295 No DAC is typically cycled as needed. Continuous dosing protocol, no cycling mentioned
Questions reflect common community inquiries. This is not medical advice.