Cortagen
Ala-Glu-Asp-Pro (AEDP)
Overview
Cortagen is a synthetic tetrapeptide bioregulator developed at the St. Petersburg Institute of Bioregulation and Gerontology targeting brain tissue and the cardiovascular system. It belongs to the same family of peptide bioregulators as Epithalon and Pinealon and has been studied for neuroprotective effects cardiovascular protection and anti-aging properties. Cortagen has shown particular promise in preclinical studies for protecting cardiac and neural tissue from ischemic damage and supporting cardiovascular function in aging populations.
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Mechanism of Action
Cortagen acts as a gene expression regulator in brain and cardiovascular tissue binding to DNA regulatory sequences and modulating transcription of genes involved in cell survival antioxidant defense and tissue homeostasis. In cardiac tissue it has demonstrated protective effects against ischemia-reperfusion injury reducing infarct size and preserving cardiac function in animal models. In neural tissue it reduces oxidative damage and supports neuronal survival under stress conditions. Like other bioregulator peptides from this research program Cortagen is thought to work by restoring gene expression patterns that drift unfavorably with aging effectively resetting cellular programs toward more youthful functional states.
Dosage Information
Typical Dose
5-10 mg daily
Frequency
Once daily for 10-day cycles
Administration
Subcutaneous injection
Notes
Part of the Russian peptide bioregulator family alongside Epithalon and Pinealon. Typically used in 10-day cycles 2-4 times per year.
Potential Side Effects
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Quick Facts
- Administration
- Subcutaneous injection
- Typical Dose
- 5-10 mg daily
- Frequency
- Once daily for 10-day cycles
- References
- 0 curated + 0 from PubMed
- Evidence Score
- 8.0 / 100