Fisetin: The Cellular Cleanup Compound
Fisetin is a natural compound found in strawberries, apples, and other fruits that's gotten serious scientific attention for fighting aging at the cellular level. Your body naturally accumulates what researchers call "zombie cells" — cells that have stopped dividing but won't die. They just sit there, leaking inflammatory chemicals that damage surrounding tissue and speed up aging. Fisetin is one of the most powerful substances found so far for identifying and eliminating these zombie cells, which is why major research institutions like Mayo Clinic are now running human trials to see if it can help with age-related diseases.
Here's how it works: Your zombie cells have basically put up a protective shield that keeps them alive even though they're damaged. Fisetin punches through that shield by blocking the survival signals that keep these cells hanging around. Think of it like cutting the life support to cells that should have already died. Importantly, fisetin is picky — it targets only the damaged zombie cells while leaving your healthy cells alone. Beyond that targeted cleanup, fisetin also reduces inflammation throughout your body, acts as an antioxidant to prevent cellular damage, and can even cross into your brain to protect nerve cells. In animal studies, it's shown real promise at reducing the cellular damage of aging.
Dosage Information
Typical Dose
20 mg/kg body weight (senolytic protocol, 2-3 days per month)
Frequency
Pulse dosing — 2-3 consecutive days per month for senolytic effect, or 100-500 mg daily for general antioxidant use
Administration
Oral capsule with fat for improved absorption
Half-Life
~3 hours
estimatedNotes
Senolytic protocols use intermittent high-dose approach rather than daily dosing. Human senolytic trials have used doses of 20mg/kg for 2 consecutive days. Fat co-administration significantly improves bioavailability.
Why this matters
Short oral half-life; senolytic protocols use high intermittent doses rather than daily low doses.
Protocol cycle
Where does Fisetin sit?
See how this peptide compares across all 150 peptides in our database.
Evidence Score
0.66
Compound Data
Molecular Formula
C15H10O6
Molecular Weight
286.24 g/mol
IUPAC Name
2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
PubChem CID
5281614Potential Side Effects
Fisetin discussions
Quick Facts
- Administration
- Oral capsule with fat for improved absorption
- Typical Dose
- 20 mg/kg body weight (senolytic protocol, 2-3 days per month)
- Frequency
- Pulse dosing — 2-3 consecutive days per month for senolytic effect, or 100-500 mg daily for general antioxidant use
- References
- 0 curated + 47 from PubMed
- Clinical Trials
- 6 registered
- Evidence Score
- 0.7 / 100
Frequently Asked Questions about Fisetin
What is Fisetin?
Fisetin is a flavonoid polyphenol found in strawberries, apples, and other fruits that has emerged as one of the most potent senolytic compounds identified — agents that selectively eliminate senescent cells ('zombie cells') that accumulate with aging and drive chronic inflammation. Research at the Mayo Clinic and the Buck Institute for Research on Aging has positioned fisetin as one of the leading senolytic candidates for clinical translation. Human clinical trials are underway for conditions including aging frailty, COVID-19 complications, Alzheimer's disease, and kidney disease, establishing fisetin as a frontline compound in the geroscience field.
How does Fisetin work?
Fisetin's primary senolytic mechanism involves inhibition of pro-survival pathways in senescent cells. Senescent cells abnormally upregulate anti-apoptotic proteins including BCL-2, BCL-XL, and PI3K/AKT that protect them from programmed cell death. Fisetin inhibits these pathways, selectively restoring apoptotic sensitivity in senescent cells while sparing normal healthy cells. Additionally fisetin activates sirtuin pathways, inhibits mTOR, and has potent antioxidant and anti-inflammatory activity through NF-κB inhibition and direct free radical scavenging. In animal models, intermittent high-dose fisetin treatment has reduced senescent cell burden, reduced inflammatory markers, and extended healthspan. Its ability to cross the blood-brain barrier also gives it potential neuroprotective applications.
What is the recommended dosage for Fisetin?
The typical dose is 20 mg/kg body weight (senolytic protocol, 2-3 days per month). Pulse dosing — 2-3 consecutive days per month for senolytic effect, or 100-500 mg daily for general antioxidant use. Administration: Oral capsule with fat for improved absorption. Senolytic protocols use intermittent high-dose approach rather than daily dosing. Human senolytic trials have used doses of 20mg/kg for 2 consecutive days. Fat co-administration significantly improves bioavailability.
What are the side effects of Fisetin?
Generally well-tolerated in animal studies. Limited human safety data at high senolytic doses. GI discomfort at high doses (uncommon). Headache (rare)
What is the Fisetin cycle protocol?
Fisetin is typically cycled 2-3 days on and ~27-28 days off. Pulse dosing monthly for senolytic effect
Questions reflect common community inquiries. This is not medical advice.