HCG: What It Does and How
HCG is a hormone that your body naturally produces during pregnancy, but it turns out it's incredibly useful for other situations too. People use it when their testosterone production has stalled—whether that's from hormone replacement therapy, steroid use, fertility issues, or just low testosterone in general. The reason it's so popular is that it keeps your testicles working and producing testosterone even when other signals in your body are telling them to shut down.
Here's how it works: Think of your testicles like a factory that needs orders to keep running. Normally, your pituitary gland sends out a messenger hormone called LH that tells your testicles "keep making testosterone." But when you're supplementing with testosterone from outside, your pituitary stops sending those signals—it figures the job's already done. That's where HCG comes in. It basically impersonates that LH messenger and directly tells your testicles to keep producing testosterone anyway. It essentially bypasses the shutdown, keeping your testicles active and maintaining their size and function. This is why it's so valuable for preserving fertility and keeping your body's natural hormone production alive while you're using other hormones.
Dosage Information
Typical Dose
250-500 IU, 2-3 times weekly (fertility/TRT adjunct)
Frequency
2-3 times weekly
Administration
Subcutaneous or intramuscular injection
Half-Life
24–36 hours
Notes
Used alongside TRT to maintain testicular size and fertility. PCT protocols typically use 1000-2500 IU every other day for 2-3 weeks post-cycle. Requires medical supervision.
Why this matters
Long half-life allows every-other-day or twice-weekly dosing.
Protocol cycle
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Evidence Score
0.71
Compound Data
Molecular Formula
C11H19N3O6S
Molecular Weight
321.35 g/mol
IUPAC Name
(2S)-2-amino-6-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-6-oxohexanoic acid
PubChem CID
4369448Potential Side Effects
HCG discussions
Quick Facts
- Administration
- Subcutaneous or intramuscular injection
- Typical Dose
- 250-500 IU, 2-3 times weekly (fertility/TRT adjunct)
- Frequency
- 2-3 times weekly
- References
- 0 curated + 46 from PubMed
- Clinical Trials
- 49 registered
- Evidence Score
- 0.7 / 100
Frequently Asked Questions about HCG
What is HCG?
Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone produced during pregnancy that mimics luteinizing hormone (LH) and stimulates testosterone production in the testes. It is FDA-approved for hypogonadism, cryptorchidism, and infertility. In the peptide research community HCG is widely used alongside testosterone replacement therapy to maintain testicular function and size, preserve fertility, and support endogenous testosterone production. It is also used in post-cycle therapy (PCT) protocols following anabolic steroid use to restore the hypothalamic-pituitary-gonadal axis.
How does HCG work?
HCG binds to LH/hCG receptors on Leydig cells in the testes, mimicking the action of luteinizing hormone and directly stimulating testosterone synthesis and secretion. Because it acts directly on the testes rather than through the HPG axis, HCG can restore testicular testosterone production even when the pituitary is suppressed by exogenous androgens. HCG also maintains testicular volume and spermatogenesis by stimulating Sertoli cells and supporting intratesticular testosterone levels required for sperm production. In women, HCG triggers ovulation by mimicking the LH surge and is used extensively in assisted reproduction. Its ability to bypass pituitary suppression makes it uniquely valuable in the context of exogenous hormone use.
What is the recommended dosage for HCG?
The typical dose is 250-500 IU, 2-3 times weekly (fertility/TRT adjunct). 2-3 times weekly. Administration: Subcutaneous or intramuscular injection. Used alongside TRT to maintain testicular size and fertility. PCT protocols typically use 1000-2500 IU every other day for 2-3 weeks post-cycle. Requires medical supervision.
What are the side effects of HCG?
Gynecomastia — due to increased estrogen conversion (uncommon). Acne (uncommon). Water retention (uncommon). Headache (rare). Injection site pain (common)
What is the HCG cycle protocol?
HCG is typically cycled 2-3 weeks. Post-cycle therapy use; continuous during TRT
Questions reflect common community inquiries. This is not medical advice.