HCG
Human Chorionic Gonadotropin
Overview
Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone produced during pregnancy that mimics luteinizing hormone (LH) and stimulates testosterone production in the testes. It is FDA-approved for hypogonadism, cryptorchidism, and infertility. In the peptide research community HCG is widely used alongside testosterone replacement therapy to maintain testicular function and size, preserve fertility, and support endogenous testosterone production. It is also used in post-cycle therapy (PCT) protocols following anabolic steroid use to restore the hypothalamic-pituitary-gonadal axis.
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Mechanism of Action
HCG binds to LH/hCG receptors on Leydig cells in the testes, mimicking the action of luteinizing hormone and directly stimulating testosterone synthesis and secretion. Because it acts directly on the testes rather than through the HPG axis, HCG can restore testicular testosterone production even when the pituitary is suppressed by exogenous androgens. HCG also maintains testicular volume and spermatogenesis by stimulating Sertoli cells and supporting intratesticular testosterone levels required for sperm production. In women, HCG triggers ovulation by mimicking the LH surge and is used extensively in assisted reproduction. Its ability to bypass pituitary suppression makes it uniquely valuable in the context of exogenous hormone use.
Dosage Information
Typical Dose
250-500 IU, 2-3 times weekly (fertility/TRT adjunct)
Frequency
2-3 times weekly
Administration
Subcutaneous or intramuscular injection
Notes
Used alongside TRT to maintain testicular size and fertility. PCT protocols typically use 1000-2500 IU every other day for 2-3 weeks post-cycle. Requires medical supervision.
Potential Side Effects
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Quick Facts
- Administration
- Subcutaneous or intramuscular injection
- Typical Dose
- 250-500 IU, 2-3 times weekly (fertility/TRT adjunct)
- Frequency
- 2-3 times weekly
- References
- 0 curated + 0 from PubMed