Kisspeptin
Kisspeptin-10 (Metastin 45-54)
Overview
Kisspeptin is a peptide encoded by the KISS1 gene that plays a master regulatory role in the hypothalamic-pituitary-gonadal (HPG) axis. It is the primary trigger for GnRH (gonadotropin-releasing hormone) secretion, which controls the release of LH and FSH — the hormones that drive testosterone and estrogen production.
Mechanism of Action
Kisspeptin binds to the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering the pulsatile release of GnRH. This activates the downstream cascade of LH and FSH release from the pituitary, which stimulates gonadal hormone production (testosterone in men, estradiol in women). It operates as the upstream "switch" of reproductive hormone signaling.
Dosage Information
Typical Dose
1-10 mcg/kg
Frequency
As directed by clinician
Administration
Subcutaneous or intravenous injection
Notes
Kisspeptin-10 is the most commonly used fragment. Dosing is highly variable and typically clinician-directed. Research doses in studies range from 0.3-10 mcg/kg. Used in fertility medicine to trigger ovulation as an alternative to hCG.
Potential Side Effects
Research References
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Quick Facts
- Administration
- Subcutaneous or intravenous injection
- Typical Dose
- 1-10 mcg/kg
- Frequency
- As directed by clinician
- References
- 2 studies