Skin HealthAnti-AgingNo data

Leuphasyl

Pentapeptide-18

Overview

Leuphasyl is a synthetic pentapeptide that acts as an enkephalin analog — mimicking endogenous opioid peptides that modulate neuromuscular signaling. It works synergistically with Argireline to produce greater muscle relaxation effects than either compound alone making it a popular co-ingredient in advanced anti-wrinkle formulations. Leuphasyl targets a complementary pathway to Argireline providing a more complete inhibition of the neuromuscular signaling cascade responsible for expression line formation.

Mechanism of Action

Leuphasyl acts as a synthetic analog of enkephalin — an endogenous opioid neuropeptide that binds to delta-opioid receptors at the neuromuscular junction. Delta-opioid receptor activation reduces the sensitivity of the neuromuscular junction to nerve impulses decreasing the muscle contraction response to normal facial expression. This mechanism is complementary to Argireline's SNARE complex interference — Argireline reduces acetylcholine release while Leuphasyl reduces the muscle's sensitivity to the acetylcholine that is released. The combination produces additive muscle relaxation effects that clinical studies have shown to be significantly greater than either peptide alone. The opioid receptor mechanism is peripherally targeted and does not produce central nervous system opioid effects.

Dosage Information

Typical Dose

4-5% concentration in topical formulation

Frequency

Twice daily application

Administration

Topical serum or cream

Notes

Most often combined with Argireline for synergistic effects. Several commercial products combine both peptides for enhanced expression line reduction.

Where does Leuphasyl sit?

See how this peptide compares across all 111 peptides in our database.

Evidence Score

0.15

Clinical trials

0.0035%

Literature

0.0630%

Community

0.0020%

Completeness

0.8815%

Compound Data

Molecular Formula

C29H39N5O7

Molecular Weight

569.60 g/mol

IUPAC Name

(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid

PubChem CID

10099522

Potential Side Effects

Excellent safety profileSkin irritation (rare)No central opioid effects at topical doses

Community Experiences

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Quick Facts

Administration: Topical serum or cream
Typical Dose: 4-5% concentration in topical formulation
Frequency: Twice daily application
References: 0 curated + 3 from PubMed
Evidence Score: 0.1 / 100