Matrixyl 3000
Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7
Matrixyl 3000
Think of your skin and joints as being held together by a structural scaffolding made of collagen — essentially the biological "glue" that keeps everything firm and functional. Over time, this scaffolding breaks down through natural wear and tear, which is why skin sags and joints deteriorate. Matrixyl 3000 is a small peptide combination designed to fix this problem by working on both sides of the equation simultaneously.
The peptide works by sending signals to your fibroblasts — the cells responsible for building collagen — telling them to ramp up production. At the same time, it puts the brakes on enzymes called matrix metalloproteinases that act like tiny scissors, cutting apart the collagen you already have. Think of it like telling your body to both build more scaffolding while also stopping the demolition crew from tearing down what's already there.
This dual action is why people use it in skin care products to reduce wrinkles and improve firmness. But the same mechanism applies to cartilage in your joints, which is why the underlying biology matters beyond just cosmetic aging — maintaining that structural matrix keeps your body functioning smoothly, whether that's your skin's appearance or your joints' mobility.
Dosage Information
Typical Dose
3-5% total peptide concentration in topical formulation
Frequency
Twice daily topical application
Administration
Topical serum or cream
Half-Life
~4 hours
estimatedNotes
Primarily used as a topical anti-aging skincare ingredient. Joint health applications are mechanistic context for the collagen matrix biology involved.
Why this matters
Topical collagen-stimulating peptide; designed for skin penetration.
Protocol cycle
Where does Matrixyl 3000 sit?
See how this peptide compares across all 150 peptides in our database.
Evidence Score
0.11
Compound Data
Molecular Formula
C39H75N7O10
Molecular Weight
802.10 g/mol
IUPAC Name
(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid
PubChem CID
9897237Potential Side Effects
Matrixyl 3000 discussions
Quick Facts
- Administration
- Topical serum or cream
- Typical Dose
- 3-5% total peptide concentration in topical formulation
- Frequency
- Twice daily topical application
- References
- 0 curated + 0 from PubMed
- Evidence Score
- 0.1 / 100
Frequently Asked Questions about Matrixyl 3000
What is Matrixyl 3000?
Matrixyl 3000 is the trade name for the combination of Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 developed by Sederma. While primarily known as a skin anti-aging ingredient the Matrixyl peptide system has broader relevance to extracellular matrix biology and collagen homeostasis applicable to joint tissue. This entry covers Matrixyl 3000 as a collagen synthesis and anti-degradation system relevant to the broader matrix biology underlying both skin aging and cartilage maintenance.
How does Matrixyl 3000 work?
Palmitoyl Tripeptide-1 acts as a matrikine stimulating fibroblast collagen synthesis through TGF-β pathway activation while Palmitoyl Tetrapeptide-7 inhibits IL-6 driven matrix metalloproteinase activity. Together they address both sides of the collagen equation — increasing synthesis while decreasing degradation. The same MMP inhibition mechanism relevant to skin collagen breakdown also applies to cartilage extracellular matrix degradation in joint disease making the underlying biology of Matrixyl 3000 relevant beyond dermatology.
What is the recommended dosage for Matrixyl 3000?
The typical dose is 3-5% total peptide concentration in topical formulation. Twice daily topical application. Administration: Topical serum or cream. Primarily used as a topical anti-aging skincare ingredient. Joint health applications are mechanistic context for the collagen matrix biology involved.
What are the side effects of Matrixyl 3000?
Excellent topical safety profile. Skin irritation (rare). No known systemic effects at topical doses
What is the Matrixyl 3000 cycle protocol?
Matrixyl 3000 is typically cycled continuous. Topical skincare product, no cycling protocol specified
Questions reflect common community inquiries. This is not medical advice.