Melanotan II

Melanotan II Acetate

AI explanation

Melanotan II Explained

Melanotan II is a synthetic peptide—basically a short chain of amino acids designed in a lab—that mimics a natural hormone your body already makes. People use it primarily to get a tan without sun exposure, but it does several other things too.

Here's what happens when you use it: the peptide circulates through your bloodstream and binds to specific receptors scattered throughout your body, kind of like keys fitting into locks. When it activates the receptors in your skin cells, those cells start producing more melanin—the same pigment that makes you tan naturally. Your skin darkens over time without needing UV rays.

But that's not all it does. The same peptide also hits receptors in your brain that control appetite and sexual function. Many people report reduced hunger and increased sexual arousal as side effects. It can even affect your metabolism and how your body uses energy.

Essentially, melanotan II hijacks your body's natural signaling system to trick your skin into producing pigment and simultaneously influence your appetite and sexual response through your central nervous system. It's one chemical messenger doing multiple jobs at once by activating different locks in different parts of your body.

Dosage Information

Typical Dose

0.25-0.5 mg

Frequency

Daily during loading phase

Evening

Administration

Subcutaneous injection

Half-Life

1–2 hours

Notes

Start with 0.1-0.25mg to assess tolerance (nausea is common initially). Loading phase of 0.5mg daily until desired tan, then maintenance 1-2x per week. UV exposure enhances results. Store reconstituted in refrigerator.

Why this matters

Short half-life but melanin effects are cumulative and persist for weeks after loading phase.

Protocol cycle

ongoing· Loading phase then maintenance 1-2x weekly

Dose Calculator

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Concentration: 2,500 mcg/mL

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Where does Melanotan II sit?

See how this peptide compares across all 150 peptides in our database.

Evidence Score

0.19

Clinical trials
0.0035%
Literature
0.2430%
Community
0.0020%
Completeness
0.7515%
1 reviews

Compound Data

Melanotan II structure

Molecular Formula

C50H69N15O9

Molecular Weight

1024.20 g/mol

IUPAC Name

(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide

PubChem CID

92432

Potential Side Effects

Nausea (common initially)Facial flushingAppetite suppressionDarkening of molesSpontaneous erectionsFatigue
Pep Talk

Melanotan II discussions

Stacking Compatibility

Quick Facts

Administration
Subcutaneous injection
Typical Dose
0.25-0.5 mg
Frequency
Daily during loading phase
References
2 curated + 1 from PubMed
Evidence Score
0.2 / 100

Frequently Asked Questions about Melanotan II

What is Melanotan II?

Melanotan II is a synthetic cyclic peptide analog of alpha-melanocyte stimulating hormone (α-MSH). It activates melanocortin receptors, producing effects on skin pigmentation (tanning), sexual function, appetite, and fat metabolism. It was originally developed at the University of Arizona as a potential tanning agent.

How does Melanotan II work?

Melanotan II is a non-selective melanocortin receptor agonist, binding to MC1R (skin pigmentation), MC3R and MC4R (sexual function, energy homeostasis), and MC5R (exocrine gland function). MC1R activation stimulates melanogenesis, darkening the skin. MC4R activation produces appetite suppression and enhances sexual arousal via central nervous system pathways.

What is the recommended dosage for Melanotan II?

The typical dose is 0.25-0.5 mg. Daily during loading phase. Administration: Subcutaneous injection. Start with 0.1-0.25mg to assess tolerance (nausea is common initially). Loading phase of 0.5mg daily until desired tan, then maintenance 1-2x per week. UV exposure enhances results. Store reconstituted in refrigerator.

What are the side effects of Melanotan II?

Nausea (common initially). Facial flushing. Appetite suppression. Darkening of moles. Spontaneous erections. Fatigue

What is the Melanotan II cycle protocol?

Melanotan II is typically cycled ongoing. Loading phase then maintenance 1-2x weekly

Questions reflect common community inquiries. This is not medical advice.