MGF
Mechano Growth Factor (IGF-1Ec)
Overview
MGF is a splice variant of IGF-1 that is expressed locally in damaged muscle tissue following mechanical stimulation (exercise or injury). It activates satellite cells (muscle stem cells) and promotes muscle repair and hypertrophy. The PEGylated form (PEG-MGF) has an extended half-life for systemic use.
Mechanism of Action
MGF is produced by alternative splicing of the IGF-1 gene in response to muscle damage. It activates satellite cells — the resident stem cells of skeletal muscle — initiating their proliferation and differentiation into new muscle fibers. This is distinct from the systemic IGF-1 pathway. MGF must be present before IGF-1 for optimal repair, creating a sequential signaling cascade.
Dosage Information
Typical Dose
200 mcg
Frequency
Post-workout
Administration
Intramuscular injection at trained muscle site
Notes
Inject bilaterally into the trained muscle group immediately post-workout. Standard MGF has a very short half-life (~5-7 minutes). PEG-MGF lasts several days and can be injected SubQ. Do not combine standard MGF with IGF-1 at the same time.
Potential Side Effects
Research References
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Stacking Compatibility
Quick Facts
- Administration
- Intramuscular injection at trained muscle site
- Typical Dose
- 200 mcg
- Frequency
- Post-workout
- References
- 2 studies