Noopept
N-phenylacetyl-L-prolylglycine ethyl ester
Overview
Noopept is a synthetic dipeptide-derived nootropic developed in Russia that is a proline-containing dipeptide structurally related to piracetam but reportedly 1000 times more potent by weight. It is approved as a nootropic supplement in Russia and has been studied in clinical trials for cognitive disorders including traumatic brain injury and age-related cognitive decline. Noopept is one of the most popular nootropic compounds globally with a large community user base and a reasonable clinical evidence base from Russian trials.
Mechanism of Action
Noopept is hydrolyzed in the body to release cycloprolylglycine — an endogenous neuropeptide that potentiates AMPA receptor activity enhancing glutamatergic neurotransmission critical for learning and memory. Noopept also increases expression of BDNF and NGF in the hippocampus and cortex supporting neuroplasticity and neuronal survival. It has demonstrated neuroprotective effects by reducing oxidative stress in neural tissue and modulating calcium channel activity to protect against excitotoxicity. Noopept additionally modulates acetylcholine neurotransmission and has shown improvements in theta and alpha brain wave activity associated with relaxed focused cognition. Its mechanism involves multiple complementary pathways rather than a single target making it distinct from single-mechanism cognitive enhancers.
Dosage Information
Typical Dose
10-30 mg daily
Frequency
Once or twice daily, taken in the morning
Administration
Oral or sublingual
Notes
Sublingual administration may provide faster onset. Start at 10mg to assess tolerance. Cycles of 1-2 months with breaks recommended. Choline supplementation alongside Noopept may reduce headache side effects.
Where does Noopept sit?
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Evidence Score
0.27
Compound Data
Molecular Formula
C17H22N2O4
Molecular Weight
318.40 g/mol
IUPAC Name
ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate
PubChem CID
180496Potential Side Effects
Community Experiences
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Quick Facts
- Administration
- Oral or sublingual
- Typical Dose
- 10-30 mg daily
- Frequency
- Once or twice daily, taken in the morning
- References
- 0 curated + 49 from PubMed
- Evidence Score
- 0.3 / 100