Quercetin
Quercetin
Overview
Quercetin is one of the most abundant dietary flavonoids, found in onions, apples, capers, and many other plant foods. It is one of the first senolytic compounds identified in landmark research by the Mayo Clinic, where the quercetin plus dasatinib combination demonstrated clearance of senescent cells in humans. Quercetin has an extensive research base spanning cardiovascular health, immune function, anti-inflammatory effects, antiviral properties, and senolytic activity. It is among the most studied plant compounds in nutritional science with hundreds of human clinical trials completed.
Where does Quercetin sit?
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Mechanism of Action
Quercetin's senolytic mechanism mirrors fisetin — inhibition of PI3K/AKT and BCL-2 pro-survival pathways that senescent cells depend on for survival, selectively restoring apoptotic sensitivity. In the landmark Mayo Clinic senolytic research, quercetin combined with dasatinib (a tyrosine kinase inhibitor) produced the first direct evidence of senescent cell clearance in humans. Beyond senolytics, quercetin inhibits NF-κB-mediated inflammatory signaling, scavenges reactive oxygen species directly, inhibits histamine release from mast cells (antihistamine effect), activates Nrf2 antioxidant response element pathways, and has demonstrated direct antiviral activity against multiple respiratory viruses including influenza and coronaviruses. Its bioavailability is enhanced significantly by co-administration with bromelain or vitamin C.
Dosage Information
Typical Dose
500-1000 mg daily (general use), 1000 mg twice daily for 3 days (senolytic protocol)
Frequency
Once or twice daily
Administration
Oral capsule, preferably with bromelain for enhanced absorption
Notes
Senolytic use typically combined with dasatinib under medical supervision. For general antioxidant and immune use, quercetin phytosome or quercetin with bromelain are preferred for improved bioavailability.
Potential Side Effects
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Quick Facts
- Administration
- Oral capsule, preferably with bromelain for enhanced absorption
- Typical Dose
- 500-1000 mg daily (general use), 1000 mg twice daily for 3 days (senolytic protocol)
- Frequency
- Once or twice daily
- References
- 0 curated + 0 from PubMed