SNAP-8
Acetyl Octapeptide-3
Overview
SNAP-8 is a synthetic octapeptide that mimics the N-terminal end of SNAP-25, a component of the SNARE complex involved in neuromuscular signaling. It competitively inhibits the SNARE complex formation, reducing muscle contraction at the neuromuscular junction. Often called "topical Botox" for its ability to reduce expression lines without injections.
Mechanism of Action
SNAP-8 is a competitive antagonist of the SNARE complex, specifically mimicking a portion of the SNAP-25 protein. By competing with native SNAP-25 for a position in the SNARE complex, it destabilizes the complex and reduces acetylcholine exocytosis at the neuromuscular junction. This decreases muscle contraction intensity, softening dynamic expression wrinkles (crow's feet, forehead lines, frown lines).
Dosage Information
Typical Dose
3-10% in formulations
Frequency
Twice daily (topical)
Administration
Topical (serum or cream)
Notes
Applied topically to areas with expression wrinkles. Most effective at 10% concentration. Results typically visible after 28 days of consistent use. Can be combined with other anti-aging actives. Only for topical use — not injected.
Potential Side Effects
Research References
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Quick Facts
- Administration
- Topical (serum or cream)
- Typical Dose
- 3-10% in formulations
- Frequency
- Twice daily (topical)
- References
- 2 studies