Syn-Coll
Palmitoyl Tripeptide-5
Overview
Syn-Coll (Palmitoyl Tripeptide-5) is a synthetic lipopeptide that mimics the natural activation mechanism of TGF-β — the primary growth factor responsible for collagen synthesis in the skin. Unlike GHK-based peptides that stimulate collagen indirectly through matrikine signaling Syn-Coll directly activates the TGF-β receptor pathway producing a more targeted collagen synthesis stimulus. It has demonstrated significant improvements in skin firmness and wrinkle reduction in clinical trials and is used in prestige anti-aging skincare formulations.
Mechanism of Action
Palmitoyl Tripeptide-5 mimics the sequence Lys-Arg-Phe-Lys from thrombospondin-1 — a naturally occurring activator of latent TGF-β. By binding to the same thrombospondin-1 receptor site on latent TGF-β this peptide triggers the conformational change that activates TGF-β releasing it from its inactive latent complex. Active TGF-β then binds to TGF-β receptors on fibroblasts activating the SMAD signaling cascade that upregulates transcription of collagen types I and III elastin and other extracellular matrix components. This direct TGF-β activation mechanism is more targeted than matrikine-based approaches and produces a strong collagen synthesis response in clinical studies.
Dosage Information
Typical Dose
4-8% concentration in topical formulation
Frequency
Once or twice daily
Administration
Topical serum or cream
Notes
Effective as a standalone anti-aging ingredient but also works synergistically with Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7) for comprehensive collagen support.
Where does Syn-Coll sit?
See how this peptide compares across all 111 peptides in our database.
Evidence Score
0.55
Compound Data
Molecular Formula
C33H65N5O5
Molecular Weight
611.90 g/mol
IUPAC Name
(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid
PubChem CID
11950477Potential Side Effects
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Quick Facts
- Administration
- Topical serum or cream
- Typical Dose
- 4-8% concentration in topical formulation
- Frequency
- Once or twice daily
- References
- 0 curated + 3 from PubMed
- Clinical Trials
- 2 registered
- Evidence Score
- 0.5 / 100