Urolithin A

Urolithin A (3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one)

AI explanation

Urolithin A: The Cellular Cleanup Crew

Urolithin A is a compound your gut bacteria naturally make when you eat pomegranates or walnuts. Think of it as a cleanup signal that tells your cells to get rid of old, broken-down mitochondria—those tiny power plants inside your cells that produce the energy you need to move and think. As you age, these mitochondria accumulate damage like old engines losing efficiency, which is why your muscles get tired faster and you have less overall energy.

Here's where urolithin A comes in: it activates your body's quality-control system, essentially telling damaged mitochondria "you're no longer useful, time to go." Your cells then break down these worn-out power plants and build fresh, healthy ones to replace them. It's like replacing old appliances in your house with new ones that actually work properly.

The result? Better muscle endurance, more consistent energy production, and less inflammation throughout your body. Clinical studies in middle-aged and older adults have shown real improvements in how long people can exercise before fatigue sets in. Because urolithin A comes from a natural pathway in your body—triggered by foods you might already eat—it's working with your biology rather than against it, making it a surprisingly elegant way to fight cellular aging at its source.

Dosage Information

Typical Dose

500-1000 mg daily

Frequency

Once daily

Morning

Administration

Oral capsule

Half-Life

17–67 hours

Notes

MitoPure (Timeline Bio) is the clinically studied standardized form. Only ~40% of people naturally produce Urolithin A from dietary sources — supplementation bypasses the gut microbiome variability. Effects on muscle endurance apparent after 4 months.

Why this matters

Long oral half-life; once-daily dosing supports sustained mitophagy activation.

Protocol cycle

continuous· Daily dosing with 4-month timeline for effects

Where does Urolithin A sit?

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Evidence Score

0.28

Clinical trials
0.0035%
Literature
0.5630%
Community
0.0020%
Completeness
0.7515%
1 RCTs

Compound Data

Urolithin A structure

Molecular Formula

C13H8O4

Molecular Weight

228.20 g/mol

IUPAC Name

3,8-dihydroxybenzo[c]chromen-6-one

PubChem CID

5488186

Potential Side Effects

Generally very well tolerated in clinical trialsMild GI upset (uncommon)No significant adverse effects at studied doses
Pep Talk

Urolithin A discussions

Quick Facts

Administration
Oral capsule
Typical Dose
500-1000 mg daily
Frequency
Once daily
References
0 curated + 48 from PubMed
Evidence Score
0.3 / 100

Frequently Asked Questions about Urolithin A

What is Urolithin A?

Urolithin A is a gut-microbiome-derived metabolite produced from ellagitannins found in pomegranate berries and walnuts. It is the most studied urolithin with potent mitophagy-inducing effects — selectively clearing damaged mitochondria to improve mitochondrial quality and muscle function. Timeline Bio's MitoPure is a standardized Urolithin A supplement that has completed Phase 2 clinical trials showing significant improvements in muscle endurance and mitochondrial function in middle-aged and elderly adults. Urolithin A represents a significant advance in targeting mitochondrial aging through a natural metabolite pathway.

How does Urolithin A work?

Urolithin A is the most potent known naturally-derived inducer of mitophagy — the selective autophagy pathway that identifies and eliminates damaged mitochondria. As mitochondria accumulate damage with aging their dysfunction impairs cellular energy production and increases oxidative stress. Urolithin A activates PINK1/Parkin-mediated mitophagy tagging damaged mitochondria for lysosomal degradation while simultaneously stimulating mitochondrial biogenesis to replace them with healthy functional mitochondria. This mitochondrial quality control improvement has been shown to increase muscle endurance ATP production and cellular resilience in clinical studies. Urolithin A also has anti-inflammatory effects through NLRP3 inflammasome inhibition and sirtuins activation contributing to its broad anti-aging profile.

What is the recommended dosage for Urolithin A?

The typical dose is 500-1000 mg daily. Once daily. Administration: Oral capsule. MitoPure (Timeline Bio) is the clinically studied standardized form. Only ~40% of people naturally produce Urolithin A from dietary sources — supplementation bypasses the gut microbiome variability. Effects on muscle endurance apparent after 4 months.

What are the side effects of Urolithin A?

Generally very well tolerated in clinical trials. Mild GI upset (uncommon). No significant adverse effects at studied doses

What is the Urolithin A cycle protocol?

Urolithin A is typically cycled continuous. Daily dosing with 4-month timeline for effects

Questions reflect common community inquiries. This is not medical advice.