LongevityPreclinical

Vilon

Lys-Glu (KE Dipeptide)

AI explanation

Vilon: A Peptide Explanation

Vilon is a tiny peptide—basically two amino acids linked together—that acts like a molecular messenger telling your cells to behave better. Researchers in Russia developed it specifically to keep your blood vessels and immune system functioning well. People are interested in it because it appears to help your body maintain healthier aging patterns, with some studies even suggesting it can extend lifespan.

Here's how it works: Your cells have DNA tucked inside their nucleus, and that DNA contains instructions for everything your cells do. Vilon is small enough to slip directly through your cell membranes and reach that DNA. Once inside, it binds to specific sections of your genetic material and essentially changes which genes get activated or turned off. In your blood vessels, it tells cells to reduce inflammatory signals and improves how your endothelial cells—the ones lining your vessels—function, which helps prevent plaque buildup. In your immune cells, it has a calming effect, dialing down excessive inflammation. Because it's so tiny, it can even cross the blood-brain barrier to affect your brain tissue. Essentially, Vilon acts as a genetic traffic controller, redirecting your cells toward healthier patterns without replacing any biological systems—just optimizing how they work.

Dosage Information

Typical Dose

0.1-1 mg daily

Frequency

Once daily for 10-day cycles

Morning

Administration

Subcutaneous injection or intranasal

Half-Life

~15 minutes

estimated

Notes

Often used in combination with Epithalon and Thymalin as part of comprehensive bioregulator protocols. Very low doses required due to high potency as a dipeptide.

Why this matters

Immune bioregulator dipeptide; rapid clearance with cumulative effects.

Protocol cycle

10 days· Part of comprehensive bioregulator protocols with other peptides

Dose Calculator

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Concentration: 2,500 mcg/mL

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Where does Vilon sit?

See how this peptide compares across all 150 peptides in our database.

Evidence Score

0.16

Clinical trials
0.0035%
Literature
0.0830%
Community
0.0020%
Completeness
0.8815%

Compound Data

Vilon structure

Molecular Formula

C11H21N3O5

Molecular Weight

275.30 g/mol

IUPAC Name

(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioic acid

PubChem CID

7010502

Potential Side Effects

Excellent safety profile in available studiesInjection site reactions (rare)Limited long-term human safety data outside Russian studies
Pep Talk

Vilon discussions

Quick Facts

Administration
Subcutaneous injection or intranasal
Typical Dose
0.1-1 mg daily
Frequency
Once daily for 10-day cycles
References
0 curated + 5 from PubMed
Evidence Score
0.2 / 100

Frequently Asked Questions about Vilon

What is Vilon?

Vilon is a synthetic dipeptide (Lys-Glu) bioregulator developed at the St. Petersburg Institute of Bioregulation and Gerontology that targets vascular and immune tissue. It is one of the smallest and most studied peptide bioregulators with regulatory effects on gene expression in vascular cells and immune tissue. Vilon has demonstrated anti-inflammatory vascular protective and immune modulating effects in both animal and human studies and is part of the comprehensive bioregulator family developed by Vladimir Khavinson's research program.

How does Vilon work?

Vilon acts as a gene expression regulator in vascular endothelial cells and immune tissue binding to specific chromatin sequences and modulating transcription of genes involved in vascular homeostasis inflammation and cell survival. In vascular tissue it reduces inflammatory cytokine production improves endothelial function and has anti-atherogenic effects. In immune cells Vilon modulates lymphocyte activity and has anti-inflammatory properties. As a dipeptide it readily penetrates cell membranes and the blood-brain barrier allowing access to nuclear DNA for its regulatory effects. Animal studies have shown significant lifespan extension with Vilon treatment and combination protocols with other bioregulators like Epithalon.

What is the recommended dosage for Vilon?

The typical dose is 0.1-1 mg daily. Once daily for 10-day cycles. Administration: Subcutaneous injection or intranasal. Often used in combination with Epithalon and Thymalin as part of comprehensive bioregulator protocols. Very low doses required due to high potency as a dipeptide.

What are the side effects of Vilon?

Excellent safety profile in available studies. Injection site reactions (rare). Limited long-term human safety data outside Russian studies

What is the Vilon cycle protocol?

Vilon is typically cycled 10 days. Part of comprehensive bioregulator protocols with other peptides

Questions reflect common community inquiries. This is not medical advice.