Fat LossRecoveryEarly research

AOD-9604

Advanced Obesity Drug 9604

AI explanation

AOD-9604 Explanation

AOD-9604 is a synthetic peptide—basically a tiny piece of human growth hormone that's been refined to do one specific job: help your body burn fat. People use it because it takes the fat-burning benefits of growth hormone while leaving behind the side effects that come with the whole hormone. Think of it like extracting the engine from a car instead of buying the whole vehicle—you get what you actually need.

Here's how it works in your body. Your body stores energy as fat through a constant back-and-forth process: fat gets broken down for energy, and fat gets stored for later. AOD-9604 tips this balance toward breakdown. It essentially flips a switch on your fat cells by activating specific receptors that tell your body to unlock stored fat and burn it for fuel. At the same time, it dampens the signals that tell your body to create new fat stores.

What makes this peptide different from taking full growth hormone is precision. It skips all the side effects like messing with your blood sugar or triggering excessive growth. Your body's fat metabolism gets a nudge in one direction while everything else stays balanced. It's a targeted approach to fat loss at the cellular level.

Dosage Information

Typical Dose

300 mcg

Frequency

Once daily

Morning

Administration

Subcutaneous injection

Half-Life

~30 minutes

estimated

Notes

Best administered in the morning on an empty stomach. Do not eat for 15-20 minutes after injection. Cycle 12 weeks on, 4 weeks off. Has GRAS (Generally Recognized as Safe) status from FDA for oral use.

Why this matters

Similar to HGH Fragment; short half-life requires morning dosing on empty stomach.

Protocol cycle

12 weeks on4 weeks off· 12 weeks on, 4 weeks off protocol

Dose Calculator

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Concentration: 2,500 mcg/mL

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Where does AOD-9604 sit?

See how this peptide compares across all 150 peptides in our database.

Evidence Score

0.09

Clinical trials
0.0035%
Literature
0.0030%
Community
0.0020%
Completeness
0.6315%

Compound Data

AOD-9604 structure

Molecular Formula

C78H123N23O23S2

Molecular Weight

1815.10 g/mol

IUPAC Name

(2S)-2-[[2-[[(4R,7S,13S,16S,19S,22S,25R)-25-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-22-(3-carbamimidamidopropyl)-13-(2-carboxyethyl)-7,19-bis(hydroxymethyl)-6,9,12,15,18,21,24-heptaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carbonyl]amino]acetyl]amino]-3-phenylpropanoic acid

PubChem CID

71300630

Potential Side Effects

Injection site irritationHeadache (mild)Indigestion (rare)Mild euphoria (uncommon)
Pep Talk

AOD-9604 discussions

Quick Facts

Administration
Subcutaneous injection
Typical Dose
300 mcg
Frequency
Once daily
References
2 curated + 0 from PubMed
Evidence Score
0.1 / 100

Frequently Asked Questions about AOD-9604

What is AOD-9604?

AOD-9604 is a modified fragment (amino acids 177-191) of the human growth hormone polypeptide with an added tyrosine at the N-terminus. It retains the fat-metabolizing properties of GH without its growth-promoting or diabetogenic effects, making it a targeted fat loss peptide.

How does AOD-9604 work?

AOD-9604 stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation) by mimicking the way natural growth hormone regulates fat metabolism. It activates beta-3 adrenergic receptors in adipose tissue. Importantly, it does not affect IGF-1 levels or insulin sensitivity, distinguishing it from full-length GH. Recent research also shows chondroprotective properties.

What is the recommended dosage for AOD-9604?

The typical dose is 300 mcg. Once daily. Administration: Subcutaneous injection. Best administered in the morning on an empty stomach. Do not eat for 15-20 minutes after injection. Cycle 12 weeks on, 4 weeks off. Has GRAS (Generally Recognized as Safe) status from FDA for oral use.

What are the side effects of AOD-9604?

Injection site irritation. Headache (mild). Indigestion (rare). Mild euphoria (uncommon)

What is the AOD-9604 cycle protocol?

AOD-9604 is typically cycled 12 weeks on and 4 weeks off. 12 weeks on, 4 weeks off protocol

Questions reflect common community inquiries. This is not medical advice.