Anti-Aging🔥Fat Loss💪Muscle Growth😴Sleep🔬Hormonal Health

Ipamorelin

Ipamorelin Acetate

Overview

Ipamorelin is one of the most selective growth hormone secretagogues available. Unlike other GH-releasing peptides, it stimulates GH release without significantly affecting cortisol, prolactin, or appetite. This selectivity makes it one of the safest and most popular peptides for anti-aging and body composition improvement.

Mechanism of Action

Ipamorelin selectively binds to the ghrelin/growth hormone secretagogue receptor (GHS-R) in the pituitary gland, triggering a dose-dependent release of growth hormone. Unlike GHRP-6 or GHRP-2, it does not significantly stimulate ACTH, cortisol, or prolactin release, making it highly selective for GH secretion only.

Dosage Information

Typical Dose

200-300 mcg

Frequency

2-3 times daily

Administration

Subcutaneous injection

Notes

Best administered on an empty stomach (at least 2 hours after eating). Pre-bed dosing is popular to enhance natural GH pulse during sleep. Often stacked with CJC-1295 for synergistic effect.

Potential Side Effects

Head rush (temporary)Mild water retentionTingling in extremitiesSleepiness post-injection

Research References

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Quick Facts

Administration
Subcutaneous injection
Typical Dose
200-300 mcg
Frequency
2-3 times daily
References
2 studies