Ipamorelin

Ipamorelin Acetate

AI explanation

Ipamorelin is a synthetic peptide that people use to naturally boost their body's production of growth hormone, primarily for anti-aging benefits and improving body composition like building muscle and losing fat. Think of it as a gentle nudge to help your body produce more of the same growth hormone it made abundantly when you were younger.

When you take ipamorelin, it travels through your bloodstream to your pituitary gland, which is like your body's master control center sitting at the base of your brain. There, it acts like a very specific key that fits into special locks called ghrelin receptors. When ipamorelin binds to these receptors, it sends a signal that says "release more growth hormone" – and your pituitary gland responds by pumping out more of this valuable hormone into your system.

What makes ipamorelin particularly appealing is its precision. Imagine other similar peptides as master keys that open multiple doors at once, potentially triggering the release of stress hormones like cortisol or affecting your appetite. Ipamorelin, however, is more like a house key that only opens one specific door – it selectively triggers growth hormone release without significantly affecting these other systems, making it a cleaner, more targeted approach to hormone optimization.

Dosage Information

Typical Dose

200-300 mcg

Frequency

2-3 times daily

Morning or evening

Administration

Subcutaneous injection

Half-Life

2 hours

Notes

Best administered on an empty stomach (at least 2 hours after eating). Pre-bed dosing is popular to enhance natural GH pulse during sleep. Often stacked with CJC-1295 for synergistic effect.

Why this matters

Short half-life; typically paired with CJC-1295 for sustained GH release.

Dose Calculator

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Concentration: 2,500 mcg/mL

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Where does Ipamorelin sit?

See how this peptide compares across all 150 peptides in our database.

Evidence Score

0.12

Clinical trials
0.0035%
Literature
0.0230%
Community
0.0020%
Completeness
0.7515%

Compound Data

Ipamorelin structure

Molecular Formula

C38H49N9O5

Molecular Weight

711.90 g/mol

IUPAC Name

(2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide

PubChem CID

9831659

Potential Side Effects

Head rush (temporary)Mild water retentionTingling in extremitiesSleepiness post-injection
Pep Talk

Ipamorelin discussions

Quick Facts

Administration
Subcutaneous injection
Typical Dose
200-300 mcg
Frequency
2-3 times daily
References
2 curated + 1 from PubMed
Evidence Score
0.1 / 100

Frequently Asked Questions about Ipamorelin

What is Ipamorelin?

Ipamorelin is one of the most selective growth hormone secretagogues available. Unlike other GH-releasing peptides, it stimulates GH release without significantly affecting cortisol, prolactin, or appetite. This selectivity makes it one of the safest and most popular peptides for anti-aging and body composition improvement.

How does Ipamorelin work?

Ipamorelin selectively binds to the ghrelin/growth hormone secretagogue receptor (GHS-R) in the pituitary gland, triggering a dose-dependent release of growth hormone. Unlike GHRP-6 or GHRP-2, it does not significantly stimulate ACTH, cortisol, or prolactin release, making it highly selective for GH secretion only.

What is the recommended dosage for Ipamorelin?

The typical dose is 200-300 mcg. 2-3 times daily. Administration: Subcutaneous injection. Best administered on an empty stomach (at least 2 hours after eating). Pre-bed dosing is popular to enhance natural GH pulse during sleep. Often stacked with CJC-1295 for synergistic effect.

What are the side effects of Ipamorelin?

Head rush (temporary). Mild water retention. Tingling in extremities. Sleepiness post-injection

Questions reflect common community inquiries. This is not medical advice.