CJC-1295 is a synthetic peptide that people use to naturally boost their body's own production of growth hormone, which tends to decline as you age. Think of it as giving your body's growth hormone factory a gentle, sustained nudge rather than flooding it with artificial hormones. People turn to it hoping to improve sleep quality, reduce body fat, enhance recovery, and combat some of the effects of aging.
Here's how it works in your body: CJC-1295 acts like a master key that fits into specific receptors in your pituitary gland, the small but mighty control center at the base of your brain. When it locks into these receptors, it signals your pituitary to release more growth hormone in natural pulses throughout the day and night. What makes CJC-1295 particularly clever is that it's been modified with something called a DAC linker, which acts like a protective coating that binds to proteins in your bloodstream. This coating prevents your body from breaking it down too quickly, so instead of lasting just minutes like natural growth hormone-releasing signals, it stays active for about a week. This means you get a steady, sustained boost in growth hormone production rather than dramatic spikes and crashes.
Dosage Information
Typical Dose
1-2 mg per week
Frequency
1-2 times per week
Administration
Subcutaneous injection
Half-Life
6–8 days
Notes
Best results when combined with a GHRP such as Ipamorelin. Administer before bed to synergize with natural GH release during sleep. Cycle 8-12 weeks on, 4 weeks off.
Why this matters
Long-acting due to DAC modification; once-weekly dosing maintains elevated GH levels.
Protocol cycle
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Evidence Score
0.09
Compound Data
Molecular Formula
C165H269N47O46
Molecular Weight
3647.20 g/mol
IUPAC Name
(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-6-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
PubChem CID
91971820Potential Side Effects
CJC-1295 discussions
Stacking Compatibility
In These Stacks
Quick Facts
- Administration
- Subcutaneous injection
- Typical Dose
- 1-2 mg per week
- Frequency
- 1-2 times per week
- References
- 2 curated + 0 from PubMed
- Evidence Score
- 0.1 / 100
Frequently Asked Questions about CJC-1295
What is CJC-1295?
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates pituitary growth hormone release. The DAC modification extends its half-life to approximately 6-8 days, allowing for less frequent dosing. It is widely used for anti-aging, fat loss, sleep improvement, and overall growth hormone optimization.
How does CJC-1295 work?
CJC-1295 binds to GHRH receptors on the anterior pituitary, stimulating the synthesis and secretion of growth hormone (GH) in a pulsatile manner. The DAC linker binds to albumin in the bloodstream, dramatically extending the half-life. This results in sustained GH elevation without the supraphysiological spikes associated with exogenous GH administration.
What is the recommended dosage for CJC-1295?
The typical dose is 1-2 mg per week. 1-2 times per week. Administration: Subcutaneous injection. Best results when combined with a GHRP such as Ipamorelin. Administer before bed to synergize with natural GH release during sleep. Cycle 8-12 weeks on, 4 weeks off.
What are the side effects of CJC-1295?
Water retention. Tingling/numbness in extremities. Fatigue. Vivid dreams. Increased hunger
What is the CJC-1295 cycle protocol?
CJC-1295 is typically cycled 3-6 months continuously on and 1 month off. Combined with GHRP, administer before bed
Questions reflect common community inquiries. This is not medical advice.