DSIP
Delta Sleep Inducing Peptide
Overview
DSIP is a neuropeptide first identified in 1977 from the blood of rabbits in an induced state of sleep. It is involved in sleep regulation, particularly the promotion of delta (slow-wave) sleep. It also has stress-protective, analgesic, and neuroendocrine regulatory properties.
Mechanism of Action
DSIP modulates sleep architecture by promoting delta (slow-wave) sleep patterns. It acts on GABA-A and glutamatergic systems, normalizes disrupted circadian patterns, and reduces cortisol and CRF activity. It also influences somatostatin and LH release, and has demonstrated anti-stress and analgesic properties through opioidergic pathway modulation.
Dosage Information
Typical Dose
100-300 mcg
Frequency
Once daily, before bed
Administration
Subcutaneous injection or intranasal
Notes
Administer 30-60 minutes before desired sleep time. Effects may be cumulative over several days of use. Can be used for jet lag recovery. SubQ or intranasal routes are both effective.
Potential Side Effects
Research References
Community Experiences
No experiences shared yet. Be the first!
Stacking Compatibility
Quick Facts
- Administration
- Subcutaneous injection or intranasal
- Typical Dose
- 100-300 mcg
- Frequency
- Once daily, before bed
- References
- 2 studies