Selank

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)

AI explanation

Selank is a synthetic peptide that people use to feel calmer and think more clearly without the drowsiness or dependency issues you'd get from traditional anxiety medications. Think of it as a gentle mental optimizer that helps your brain function better under stress while keeping you alert and focused.

When you take Selank, it works like a skilled conductor orchestrating your brain's natural calming systems. Your body already produces its own anxiety-relieving compounds called enkephalins, but they usually break down quickly. Selank blocks the enzymes that destroy these natural mood stabilizers, so they stick around longer and keep working to calm your nerves. It's like putting a protective shield around your body's built-in stress relief team.

At the same time, Selank encourages your brain to produce more BDNF, which is essentially fertilizer for your brain cells. This helps your neurons grow stronger connections and communicate more efficiently, which is why people often feel mentally sharper when using it. The peptide also fine-tunes your brain's chemical balance by adjusting how your neurons use GABA and serotonin – two key messengers that control mood and relaxation. Rather than forcing dramatic changes, Selank gently nudges your brain's existing systems to work more harmoniously together.

Dosage Information

Typical Dose

250-500 mcg

Frequency

2-3 times daily

Morning

Administration

Intranasal spray or subcutaneous injection

Half-Life

1–3 minutes

Notes

Intranasal delivery provides rapid CNS effects. Each nostril typically receives one spray. Effects are noticeable within 15-30 minutes. No tolerance or dependence has been observed in clinical studies.

Why this matters

Very short systemic half-life; nasal route bypasses first-pass metabolism for CNS delivery.

Protocol cycle

as needed· No tolerance or dependence observed clinically

Dose Calculator

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Concentration: 2,500 mcg/mL

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Where does Selank sit?

See how this peptide compares across all 150 peptides in our database.

Evidence Score

0.64

Clinical trials
1.0035%
Literature
0.5430%
Community
0.0020%
Completeness
0.8815%
1 RCTs1 clinical trials

Compound Data

Selank structure

Molecular Formula

C33H57N11O9

Molecular Weight

751.90 g/mol

IUPAC Name

(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid

PubChem CID

11765600

Potential Side Effects

Nasal irritationMild fatigueHeadache (rare)Slight sedation at higher doses
Pep Talk

Selank discussions

Stacking Compatibility

Quick Facts

Administration
Intranasal spray or subcutaneous injection
Typical Dose
250-500 mcg
Frequency
2-3 times daily
References
2 curated + 50 from PubMed
Clinical Trials
10 registered
Evidence Score
0.6 / 100

Frequently Asked Questions about Selank

What is Selank?

Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it is approved in Russia as an anxiolytic and nootropic. It offers cognitive enhancement and anxiety reduction without sedation or addiction potential.

How does Selank work?

Selank modulates the expression of brain-derived neurotrophic factor (BDNF) and influences the balance of Th1/Th2 cytokines. It inhibits enkephalinase enzymes, prolonging the activity of endogenous enkephalins (the body's natural anxiolytic peptides). It also modulates GABA neurotransmission, serotonin metabolism, and has documented effects on IL-6 and interferon expression.

What is the recommended dosage for Selank?

The typical dose is 250-500 mcg. 2-3 times daily. Administration: Intranasal spray or subcutaneous injection. Intranasal delivery provides rapid CNS effects. Each nostril typically receives one spray. Effects are noticeable within 15-30 minutes. No tolerance or dependence has been observed in clinical studies.

What are the side effects of Selank?

Nasal irritation. Mild fatigue. Headache (rare). Slight sedation at higher doses

What is the Selank cycle protocol?

Selank is typically cycled as needed. No tolerance or dependence observed clinically

Questions reflect common community inquiries. This is not medical advice.