Gonadorelin
Gonadotropin-Releasing Hormone
Overview
Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH), the hypothalamic peptide that triggers the release of FSH and LH from the pituitary gland. It is FDA-approved for evaluating hypothalamic-pituitary-gonadal function and for treating conditions including endometriosis, prostate cancer, and infertility. In the testosterone replacement therapy community, gonadorelin has emerged as an alternative to HCG for maintaining testicular function during exogenous testosterone use, particularly following supply disruptions and regulatory changes affecting HCG availability.
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Mechanism of Action
Gonadorelin acts on GnRH receptors in the anterior pituitary gland, stimulating the synthesis and pulsatile release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These gonadotropins then act on the testes to stimulate testosterone production and spermatogenesis. Pulsatile gonadorelin administration mimics the natural hypothalamic GnRH release pattern and maintains pituitary sensitivity, whereas continuous administration paradoxically desensitizes GnRH receptors and suppresses gonadotropin release — the mechanism exploited by GnRH agonists used in prostate cancer treatment. In TRT contexts, pulsatile subcutaneous dosing is used to maintain the pituitary-testicular axis during periods of hypothalamic suppression from exogenous testosterone.
Dosage Information
Typical Dose
100 mcg per dose
Frequency
Twice daily (pulsatile protocol for TRT adjunct)
Administration
Subcutaneous injection
Notes
Must be dosed in a pulsatile pattern to maintain pituitary sensitivity. Continuous infusion causes desensitization and suppression — the opposite of the intended effect.
Potential Side Effects
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Quick Facts
- Administration
- Subcutaneous injection
- Typical Dose
- 100 mcg per dose
- Frequency
- Twice daily (pulsatile protocol for TRT adjunct)
- References
- 0 curated + 0 from PubMed