Clinical Evidence

Peptides with completed or active human clinical trials. These compounds have the strongest evidence base, with data from controlled studies in human subjects.

Looking for preclinical and animal study data? View all research

96 trialsPhase 4

Oxytocin

Oxytocin

Oxytocin is a nine-amino acid neuropeptide hormone produced in the hypothalamus. Often called the "love hormone" or "bonding hormone," it plays crucia...

Mood & AnxietySexual Health
Well-evidencedHuman trialsLearn more
10 trialsPhase 4

PT-141

Bremelanotide

PT-141 (Bremelanotide) is a melanocortin receptor agonist originally developed from Melanotan II research. Unlike PDE5 inhibitors that work on blood f...

Sexual HealthMood & Anxiety
Well-evidencedHuman trialsLearn more
62 trialsPhase 4

Thymosin Alpha 1

Thymalfasin (Thymosin Alpha 1)

Thymosin Alpha 1 is a 28-amino acid peptide naturally produced by the thymus gland that plays a critical role in immune system maturation and regulati...

Immune SupportAnti-AgingLongevity
Well-evidencedHuman trialsLearn more
23 trialsPhase 3

Melanotan I

Afamelanotide

Melanotan I (Afamelanotide) is a synthetic alpha-melanocyte-stimulating hormone (alpha-MSH) analog approved in Europe and Australia under the brand na...

Skin Health
Well-evidencedHuman trialsLearn more
47 trialsPhase 4

GLP-1

Glucagon-like Peptide-1

Glucagon-like Peptide-1 (GLP-1) is an endogenous incretin hormone secreted by L-cells in the small intestine in response to food intake. It plays a ce...

Fat Loss
Well-evidencedHuman trialsLearn more
49 trialsPhase 3

IGF-1

Insulin-like Growth Factor 1

Insulin-like Growth Factor 1 (IGF-1) is a naturally occurring 70-amino-acid peptide hormone produced primarily in the liver in response to growth horm...

Muscle GrowthAnti-AgingLongevity
Well-evidencedHuman trialsLearn more
12 trialsPhase 4

Pentosan Polysulfate

Pentosan Polysulfate Sodium (PPS)

Pentosan Polysulfate is a semi-synthetic polysulfated xylan derived from beechwood hemicellulose. It is FDA-approved (brand name Elmiron) for intersti...

Joint HealthRecovery
Well-evidencedHuman trialsLearn more
Featured
49 trialsPhase 4

Semaglutide

Semaglutide

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist originally developed for type 2 diabetes management and approved by the FDA under th...

Fat Loss
Well-evidencedHuman trialsLearn more
12 trialsPhase 4

LL-37

LL-37 (Human Cathelicidin)

LL-37 is the only cathelicidin antimicrobial peptide found in humans. It is a 37-amino acid peptide that serves as a critical component of the innate...

Immune SupportRecoveryGut Health
Well-evidencedHuman trialsLearn more
50 trialsPhase 4

Resveratrol

trans-Resveratrol

Resveratrol is a polyphenolic stilbene compound found in red wine, grapes, and certain berries that has been extensively studied for its potential lon...

LongevityAnti-Aging
EstablishedHuman trialsLearn more
33 trialsPhase 4

Liraglutide

Liraglutide

Liraglutide is a GLP-1 receptor agonist approved by the FDA for type 2 diabetes (Victoza) and obesity management (Saxenda). It was the first GLP-1 ana...

Fat Loss
EstablishedHuman trialsLearn more
70 trialsPhase 4

DSIP

Delta Sleep Inducing Peptide

DSIP is a neuropeptide first identified in 1977 from the blood of rabbits in an induced state of sleep. It is involved in sleep regulation, particular...

SleepMood & AnxietyRecovery
EstablishedHuman trialsLearn more
49 trialsPhase 4

Rapamycin

Sirolimus

Rapamycin (Sirolimus) is a macrolide compound originally discovered in soil bacteria from Easter Island (Rapa Nui) that functions as a potent mTOR inh...

LongevityAnti-Aging
EstablishedHuman trialsLearn more
50 trialsPhase 4

VIP

Vasoactive Intestinal Peptide

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide found throughout the central and peripheral nervous system gastrointestinal tract...

Gut Health
EstablishedHuman trialsLearn more
10 trialsPhase 3

Selank

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)

Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin. Developed at the Institute of Molecular Genetic...

Mood & AnxietyCognitive EnhancementImmune Support
EstablishedHuman trialsLearn more
6 trialsPhase 2

Fisetin

3,3',4',7-tetrahydroxyflavone

Fisetin is a flavonoid polyphenol found in strawberries, apples, and other fruits that has emerged as one of the most potent senolytic compounds ident...

LongevityAnti-Aging
EstablishedHuman trialsLearn more
46 trialsPhase 4

Alpha-MSH

Alpha-Melanocyte-Stimulating Hormone

Alpha-MSH is a 13-amino-acid endogenous peptide produced from proopiomelanocortin (POMC) in the pituitary gland skin and brain. It is the natural liga...

Skin HealthFat Loss
EstablishedHuman trialsLearn more
98 trialsPhase 4

NAD+

Nicotinamide Adenine Dinucleotide

NAD+ is a critical coenzyme found in every cell of the body, essential for hundreds of metabolic processes including energy production, DNA repair, ge...

Anti-AgingLongevityMitochondrial Health
EstablishedHuman trialsLearn more
50 trialsPhase 4

GDF-11

Growth Differentiation Factor 11

GDF-11 (Growth Differentiation Factor 11) is a TGF-beta superfamily member that generated enormous scientific excitement following 2013-2014 research...

LongevityAnti-AgingMuscle Growth
EstablishedHuman trialsLearn more
Featured
17 trialsPhase 3

TB-500

Thymosin Beta-4

TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring 43-amino-acid peptide present in virtually all human and animal cells. It play...

RecoveryJoint HealthSkin HealthImmune Support
EstablishedHuman trialsLearn more
Featured
39 trialsPhase 4

Tirzepatide

Tirzepatide

Tirzepatide is a first-in-class dual GIP/GLP-1 receptor agonist approved by the FDA under the brand name Mounjaro for type 2 diabetes and Zepbound for...

Fat Loss
EstablishedHuman trialsLearn more
1 trialPhase 2

GHRP-2

Growth Hormone Releasing Peptide-2

GHRP-2 is considered one of the most potent growth hormone releasing peptides available. It stimulates GH release more effectively than GHRP-6 with le...

Muscle GrowthFat LossAnti-AgingHormonal Health
EstablishedHuman trialsLearn more
3 trialsPhase 3

Kisspeptin

Kisspeptin-10 (Metastin 45-54)

Kisspeptin is a peptide encoded by the KISS1 gene that plays a master regulatory role in the hypothalamic-pituitary-gonadal (HPG) axis. It is the prim...

Hormonal HealthSexual Health
EmergingHuman trialsLearn more
4 trialsPhase 2

NSI-189

NSI-189 Phosphate

NSI-189 is a synthetic aminopyridine-benzylpiperazine compound originally developed by Neuralstem Inc that has demonstrated neurogenic properties in t...

PreclinicalHuman trialsLearn more
1 trialPhase 4

Tesamorelin

Tesamorelin Acetate

Tesamorelin is a synthetic GHRH analog that is FDA-approved for the treatment of HIV-associated lipodystrophy. It is the only GHRH peptide with full F...

Fat LossAnti-AgingHormonal Health
PreclinicalHuman trialsLearn more
1 trialPhase 2

Cerebrolysin

Cerebrolysin (Porcine Brain-Derived Peptide Preparation)

Cerebrolysin is a multi-modal neuropeptide preparation derived from purified porcine brain proteins. It contains a mixture of low-molecular-weight neu...

Cognitive EnhancementRecovery
PreclinicalHuman trialsLearn more

PT-141

Bremelanotide

PT-141 (Bremelanotide) is a melanocortin receptor agonist originally developed from Melanotan II research and FDA-approved in 2019 under the brand nam...

Sexual Health
No dataHuman trialsLearn more