KPV
KPV Tripeptide (Lys-Pro-Val)
Overview
KPV is a naturally occurring anti-inflammatory tripeptide derived from the C-terminal end of alpha-melanocyte stimulating hormone (α-MSH). It retains the powerful anti-inflammatory properties of α-MSH without its melanogenic (tanning) effects. It is particularly promising for gut inflammation and skin conditions.
Mechanism of Action
KPV enters cells and translocates to the nucleus where it inhibits NF-κB activation, the master regulator of inflammatory gene expression. It reduces production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and inhibits nitric oxide synthase. Its oral bioavailability makes it unique among peptides for treating gastrointestinal inflammation, particularly in IBD and IBS contexts.
Dosage Information
Typical Dose
200-500 mcg
Frequency
Once daily
Administration
Oral capsule or topical
Notes
Oral administration is effective for gut-related inflammation. Topical application for skin conditions. Can be compounded into capsules for convenient oral dosing. Well-absorbed orally, which is unusual for peptides.
Potential Side Effects
Research References
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Stacking Compatibility
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Quick Facts
- Administration
- Oral capsule or topical
- Typical Dose
- 200-500 mcg
- Frequency
- Once daily
- References
- 2 studies