Semax

Semax (Met-Glu-His-Phe-Pro-Gly-Pro)

AI explanation

Semax is a synthetic peptide that acts like a powerful brain booster, originally developed by Russian scientists for treating strokes and cognitive problems. Think of it as a master key that unlocks your brain's ability to grow stronger and work better. People use it because it's one of the most potent compounds available for enhancing mental performance, memory, and overall brain health.

When you take Semax, it works like a skilled gardener tending to your brain. It dramatically increases the production of special growth factors called BDNF and NGF in your hippocampus and cortex – the areas responsible for learning and memory. These growth factors are like fertilizer for your brain cells, helping them form new connections and even growing entirely new neurons.

At the same time, Semax fine-tunes your brain's chemical messaging system by balancing serotonin and dopamine – the neurotransmitters that control your mood, focus, and motivation. It also improves blood flow to your brain, ensuring your neurons get all the oxygen and nutrients they need to perform at their peak. Additionally, it acts like a protective shield, defending your brain cells from damage caused by stress and aging. The result is a brain that thinks clearer, remembers better, and stays resilient against decline.

Dosage Information

Typical Dose

200-600 mcg

Frequency

2-3 times daily

Morning or evening

Administration

Intranasal spray or subcutaneous injection

Half-Life

1–3 minutes

Notes

Available in 0.1% and 1% nasal spray formulations. The 1% (N-Acetyl Semax) version is more potent. Effects are rapid via intranasal route. Typically cycled 2-4 weeks on, 2 weeks off.

Why this matters

Extremely short plasma half-life; intranasal delivery provides rapid brain uptake before degradation.

Protocol cycle

2-4 weeks on2 weeks off· Standard cycling protocol for intranasal Semax

Dose Calculator

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Concentration: 2,500 mcg/mL

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Where does Semax sit?

See how this peptide compares across all 150 peptides in our database.

Evidence Score

0.18

Clinical trials
0.0035%
Literature
0.2230%
Community
0.0020%
Completeness
0.7515%

Compound Data

Semax structure

Molecular Formula

C37H51N9O10S

Molecular Weight

813.90 g/mol

IUPAC Name

(2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid

PubChem CID

9811102

Potential Side Effects

Nasal drynessMild irritabilityInsomnia (if taken too late)Hair shedding (rare, temporary)
Pep Talk

Semax discussions

Stacking Compatibility

Quick Facts

Administration
Intranasal spray or subcutaneous injection
Typical Dose
200-600 mcg
Frequency
2-3 times daily
References
3 curated + 19 from PubMed
Evidence Score
0.2 / 100

Frequently Asked Questions about Semax

What is Semax?

Semax is a synthetic peptide analog of ACTH(4-10), a fragment of adrenocorticotropic hormone. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it is approved in Russia for stroke recovery, cognitive disorders, and peptic ulcers. It is one of the most potent nootropic peptides available.

How does Semax work?

Semax significantly upregulates BDNF and NGF expression in the hippocampus and cortex, promoting neuroplasticity and neurogenesis. It modulates serotonin and dopamine neurotransmitter systems, enhances cerebral blood flow, and has neuroprotective effects against oxidative stress. It does not affect cortisol levels despite being derived from ACTH.

What is the recommended dosage for Semax?

The typical dose is 200-600 mcg. 2-3 times daily. Administration: Intranasal spray or subcutaneous injection. Available in 0.1% and 1% nasal spray formulations. The 1% (N-Acetyl Semax) version is more potent. Effects are rapid via intranasal route. Typically cycled 2-4 weeks on, 2 weeks off.

What are the side effects of Semax?

Nasal dryness. Mild irritability. Insomnia (if taken too late). Hair shedding (rare, temporary)

What is the Semax cycle protocol?

Semax is typically cycled 2-4 weeks on and 2 weeks off. Standard cycling protocol for intranasal Semax

Questions reflect common community inquiries. This is not medical advice.