Dihexa
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)
Overview
Dihexa is a synthetic peptide derivative of Angiotensin IV, developed at Washington State University. It is one of the most potent pro-cognitive compounds ever described in scientific literature, estimated to be approximately 10 million times more potent than BDNF at promoting new synaptic connections. It was developed for potential Alzheimer's disease treatment.
Mechanism of Action
Dihexa binds to hepatocyte growth factor (HGF) and its receptor c-Met, potentiating HGF/c-Met signaling. This activates the PI3K/Akt pathway, promoting dendritic spine formation, synaptogenesis, and neuronal connectivity. It crosses the blood-brain barrier and has been shown to reverse cognitive deficits in animal models by augmenting synaptic connectivity in the hippocampus and prefrontal cortex.
Dosage Information
Typical Dose
10-20 mg
Frequency
Once daily
Administration
Oral (sublingual or capsule)
Notes
Oral bioavailability makes Dihexa convenient to use. Sublingual administration may enhance absorption. Typically cycled 4-8 weeks. Very limited human clinical data — dosing is largely based on animal research extrapolation.
Potential Side Effects
Research References
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Quick Facts
- Administration
- Oral (sublingual or capsule)
- Typical Dose
- 10-20 mg
- Frequency
- Once daily
- References
- 2 studies