Anti-AgingLongevitySleepImmune SupportPreclinical

Epitalon

Epitalon (Ala-Glu-Asp-Gly)

Overview

Epithalon is a synthetic tetrapeptide based on Epithalamin, the natural peptide produced by the pineal gland. Developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology, it is one of the most studied anti-aging peptides. Its primary mechanism is the activation of telomerase, the enzyme responsible for maintaining telomere length.

Mechanism of Action

Epithalon activates telomerase, the enzyme that adds telomeric repeats (TTAGGG) to the ends of chromosomes, counteracting the shortening that occurs with each cell division. It also normalizes circadian rhythm via melatonin regulation, modulates antioxidant enzyme expression, influences neuroendocrine regulation, and has demonstrated immune-modulatory properties in clinical studies.

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Dosage Information

Typical Dose

5-10 mg

Frequency

Daily for 10-20 day cycles

Administration

Subcutaneous or intravenous injection

Notes

Typically administered in 10-20 day cycles, 2-3 times per year. SubQ is the most common route. Evening administration may enhance circadian benefits. Professor Khavinson recommends 10mg daily for 10 days, repeated every 6 months.

Dose Calculator

Calculate your draw amount for an insulin syringe (U-100)

Reconstitution

Vial size

Water added

Concentration: 2,500 mcg/mL

Desired dose

This dose requires more than one full syringe. Consider using a larger water volume to reduce concentration, or splitting into multiple injections.

Draw to the

200

unit mark

Draw 200 units for your 5000mcg dose of Epitalon

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Compound Data

Molecular Formula

C14H22N4O9

Molecular Weight

390.35 g/mol

IUPAC Name

(4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

PubChem CID

219042

Potential Side Effects

Injection site irritationMild fatigue during cycleVivid dreamsHeadache (rare)

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Stacking Compatibility

NAD+

MOTS-c

Humanin

In These Stacks

Longevity & Anti-Aging

Cellular rejuvenation and biological age reduction

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Quick Facts

Administration: Subcutaneous or intravenous injection
Typical Dose: 5-10 mg
Frequency: Daily for 10-20 day cycles
References: 3 curated + 49 from PubMed
Evidence Score: 33.9 / 100