⏳Anti-Aging🧬Longevity⚡Mitochondrial Health

NAD+

Nicotinamide Adenine Dinucleotide

Overview

NAD+ is a critical coenzyme found in every cell of the body, essential for hundreds of metabolic processes including energy production, DNA repair, gene expression, and cellular signaling. NAD+ levels decline significantly with age, and its restoration is considered a key strategy in anti-aging medicine.

Mechanism of Action

NAD+ serves as a substrate for sirtuins (SIRT1-7), enzymes critical for DNA repair, gene silencing, and metabolic regulation. It is essential for the electron transport chain in mitochondria (energy production). It activates PARP enzymes for DNA repair and CD38/CD157 for immune function. Declining NAD+ levels are associated with virtually all hallmarks of aging.

Dosage Information

Typical Dose

100-500 mg

Frequency

Varies by route

Administration

Intravenous, subcutaneous, or oral (as precursors NMN/NR)

Notes

IV infusion (250-500mg over 2-4 hours) produces the most immediate effects but is expensive. SubQ injections of 50-100mg are gaining popularity. Oral precursors (NMN, NR) at 250-1000mg daily are the most accessible option. IV sessions often produce temporary flu-like symptoms.