Epithalon
Epitalon (Ala-Glu-Asp-Gly)
Overview
Epithalon is a synthetic tetrapeptide based on Epithalamin, the natural peptide produced by the pineal gland. Developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology, it is one of the most studied anti-aging peptides. Its primary mechanism is the activation of telomerase, the enzyme responsible for maintaining telomere length.
Mechanism of Action
Epithalon activates telomerase, the enzyme that adds telomeric repeats (TTAGGG) to the ends of chromosomes, counteracting the shortening that occurs with each cell division. It also normalizes circadian rhythm via melatonin regulation, modulates antioxidant enzyme expression, influences neuroendocrine regulation, and has demonstrated immune-modulatory properties in clinical studies.
Dosage Information
Typical Dose
5-10 mg
Frequency
Daily for 10-20 day cycles
Administration
Subcutaneous or intravenous injection
Notes
Typically administered in 10-20 day cycles, 2-3 times per year. SubQ is the most common route. Evening administration may enhance circadian benefits. Professor Khavinson recommends 10mg daily for 10 days, repeated every 6 months.
Potential Side Effects
Research References
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Quick Facts
- Administration
- Subcutaneous or intravenous injection
- Typical Dose
- 5-10 mg
- Frequency
- Daily for 10-20 day cycles
- References
- 3 studies