LongevityPreclinical

SS-31 (Elamipretide)

Elamipretide (D-Arg-2'6'-dimethylTyr-Lys-Phe-NH2)

AI explanation

SS-31: A Peptide That Fixes Your Cellular Power Plants

SS-31 is a tiny protein fragment that does something pretty remarkable—it travels inside your cells to fix the machinery that powers everything you do. People are studying it because it seems to restore energy production that naturally declines with age, which is why researchers are testing it for heart problems and muscle weakness.

Here's how it works: Your cells contain structures called mitochondria that are basically tiny power plants, burning fuel to create the energy your body runs on. Inside those power plants is a specific molecule called cardiolipin that acts like the scaffolding holding the energy-making machinery together. Over time, especially as you age, that scaffolding gets damaged and falls apart, so your cells produce energy less efficiently.

SS-31 is charged like a magnet—it gets drawn specifically to the inner part of your mitochondria where cardiolipin sits. Once it arrives, it acts like glue, stabilizing that damaged scaffolding. When the scaffolding is stable again, your mitochondrial machinery runs cleaner and more efficiently. You get better energy production, less cellular damage from the process, and remarkably, studies show aged mitochondria can start working like younger ones again within hours of SS-31 arriving.

Dosage Information

Typical Dose

40 mg daily

Frequency

Once daily (clinical trials)

Anytime

Administration

Subcutaneous injection

Half-Life

3–4 hours

Notes

Clinical trial dosing has used 4-40mg SubQ daily. Research is ongoing for optimal dosing in various conditions. Primary clinical development is focused on Barth syndrome and heart failure. Not yet FDA approved.

Why this matters

Mitochondria-targeted peptide (elamipretide); once-daily subcutaneous dosing in trials.

Protocol cycle

continuous· Daily subcutaneous injection, dosing under clinical investigation

Dose Calculator

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Concentration: 2,500 mcg/mL

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Where does SS-31 (Elamipretide) sit?

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Evidence Score

0.29

Clinical trials
0.0035%
Literature
0.5930%
Community
0.0020%
Completeness
0.7515%
1 RCTs6 reviews

Compound Data

SS-31 (Elamipretide) structure

Molecular Formula

C32H49N9O5

Molecular Weight

639.80 g/mol

IUPAC Name

(2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide

PubChem CID

11764719

Potential Side Effects

Injection site reactionsHeadacheNauseaDizzinessContact dermatitis (uncommon)
Pep Talk

SS-31 (Elamipretide) discussions

Stacking Compatibility

Quick Facts

Administration
Subcutaneous injection
Typical Dose
40 mg daily
Frequency
Once daily (clinical trials)
References
2 curated + 49 from PubMed
Evidence Score
0.3 / 100

Frequently Asked Questions about SS-31 (Elamipretide)

What is SS-31 (Elamipretide)?

SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane. It stabilizes cardiolipin, a critical phospholipid required for optimal electron transport chain function. It has been in clinical trials for heart failure, mitochondrial myopathy, and age-related mitochondrial dysfunction.

How does SS-31 (Elamipretide) work?

SS-31 carries a 3+ net charge that drives its accumulation at the inner mitochondrial membrane, where it binds to cardiolipin. This stabilizes the electron transport chain complexes, reduces electron leak, decreases reactive oxygen species (ROS) production, and improves ATP synthesis efficiency. It can restore age-related declines in mitochondrial function and has been shown to rejuvenate aged mitochondria within hours.

What is the recommended dosage for SS-31 (Elamipretide)?

The typical dose is 40 mg daily. Once daily (clinical trials). Administration: Subcutaneous injection. Clinical trial dosing has used 4-40mg SubQ daily. Research is ongoing for optimal dosing in various conditions. Primary clinical development is focused on Barth syndrome and heart failure. Not yet FDA approved.

What are the side effects of SS-31 (Elamipretide)?

Injection site reactions. Headache. Nausea. Dizziness. Contact dermatitis (uncommon)

What is the SS-31 (Elamipretide) cycle protocol?

SS-31 (Elamipretide) is typically cycled continuous. Daily subcutaneous injection, dosing under clinical investigation

Questions reflect common community inquiries. This is not medical advice.